What is the primary concern regarding the use of Bupropion?

The primary concern regarding the use of Bupropion is its contraindication in patients with active eating disorders. Bupropion can increase the risk of seizures in individuals with conditions that are associated with electrolyte imbalances, which can be common in eating disorders due to factors like malnutrition, dehydration, or electrolyte disturbances. This potential for triggering seizures makes it particularly important to avoid prescribing Bupropion to patients who have these conditions.

Understanding this risk emphasizes the need for careful assessment of a patient's history and health status before initiating treatment with Bupropion. Although weight gain is not typically associated with Bupropion, as it is often noted for being weight-neutral or even weight-reducing, the other statements about its effectiveness in anxiety disorders or restrictions in older adults do not reflect the primary concern related to its use.