What is the recommended age range for women with deleterious BRCA1/2 mutations to undergo prophylactic bilateral salpingo-oophorectomy?

The recommended age range for women with deleterious BRCA1/2 mutations to undergo prophylactic bilateral salpingo-oophorectomy is generally considered to be between 35 to 40 years. This recommendation is based on the increased risk of developing ovarian cancer in women with these mutations, as well as the average age at which ovarian cancer is diagnosed.

The rationale behind this timing involves balancing the reduced risk of ovarian cancer after the procedure with concerns about the potential impact on fertility and overall health. Women who carry BRCA1 or BRCA2 mutations have a significantly heightened risk of developing ovarian cancer, and prophylactic salpingo-oophorectomy is a preventive measure that can substantially reduce this risk.

By targeting the procedure at around 35 to 40 years, healthcare providers aim to mitigate the risks of ovarian cancer while allowing for family planning options before the procedure is performed. This age bracket is also recommended considering the approach to surveillance for breast cancer, which is often another concern for women with these mutations. Women are encouraged to discuss their individual circumstances, including their family planning goals and personal preferences, when making decisions about prophylactic surgery.